Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions

Editor Profile: Guest Editors of the Special Issue “Functional Materials, Nanocarriers, and Formulations for Targeted Therapy”

16/j.aps inese P an open espons Prof. Zhonggao Gao is a Professor of the Chinese Academy of Medical Sciences, Vice President in the Department of Pharmaceutics, Institute of Materia Medica. He received a Ph. D. degree in Pharmacy in 1998, from Seoul National University, Seoul, Republic of Korea, and a Bachelor's degree in pharmacy in 1986, from YanBian University, Yanji, China. Prof. Gao is aut...

Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy.

BACKGROUND Drug delivery in polymeric micelles combined with tumor irradiation by ultrasound results in effective drug targeting, but this technique requires prior tumor imaging. A technology that combined ultrasound imaging with ultrasound-mediated nanoparticle-based targeted chemotherapy could therefore have important applications in cancer treatment. METHODS Mixtures of drug-loaded polymer...

Optimization of perfluorocarbon nanoemulsions for molecular imaging by 19F MRI

Imaging the delivery of drug-loaded, iron-stabilized micelles.

Nanoparticle drug carriers hold potential to improve current cancer therapy by delivering payload to the tumor environment and decreasing toxic side effects. Challenges in nanotechnology drug delivery include plasma instability, site-specific delivery, and relevant biomarkers. We have developed a triblock polymer comprising a hydroxamic acid functionalized center block that chelates iron to for...

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles.

The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor tissue under the action of tumor-directed therapeutic ultrasound. Tumor accumulation of nanoemulsions was confirmed by ultrasound imaging. Dramatic regression of ovarian, breast, and orthotopic pancreatic tumors was o...